January is not just a time for celebrating, visiting with family, setting and breaking New Year’s resolutions, but it is also the month that is dedicated to raising awareness for cervical health. Cervical cancer is the fourth most common cancer in women worldwide, and 80% of mortalities from cervical cancer are from developing co<a href="https://bme.fiu.edu/wp-content/uploads/2018/02/ramella-research-2.png"><img class="size-medium wp-image-14752 alignright" src="https://bme.fiu.edu/wp-content/uploads/2018/02/ramella-research-2-233x300.png" alt="" width="233" height="300" /></a>untries that lack effective screening programs. Like all cancers, early detection and diligent monitoring increase the patients’ chances for successful treatment.

Understanding this pressing need, Dr. Jessica Ramella-Roman and her team of graduate students developed a cost effective and hand-held device that uses optical technologies to detect subtle changes in cervical tissue that may indicate early stage cancer.

Clinicians and researchers have used optical technologies in cervical cancer detection devices for use in low resource settings before; however, limitations such as poor healthcare infrastructures and a lack of accessible pathologists have restricted their success. Using Mueller Matrix imaging, a modality that uses polarized light to highlight small changes in cervical tissue that are typical of this disease, Dr. Ramella-Roman’s team developed a device that can be used by a person with limited training. To test their system, they collaborated with Dr. Purnima Madhivanan, Associate Professor of Epidemiology in the Stempel College of Public Health at FIU and Director of the Public Health Research Institute of India (PHRII) in Mysore, India. They travelled to Mysore where they screened a group of twenty-three volunteers in health camps in the surrounding of Mysore as well at the PHRII clinical facility to test the performance of the device for detection of cervical cancer.<a href="https://bme.fiu.edu/wp-content/uploads/2018/02/ramella-research-1.png"><img class="size-medium wp-image-14751 aligncenter" src="https://bme.fiu.edu/wp-content/uploads/2018/02/ramella-research-1-300x121.png" alt="" width="300" height="121" /></a>

The acceptability and ease of use of the device were rigorously tested. The vast majority of practitioners and patients were interested in the imaging procedure, that ultimately could speed up the diagnostic process. Further work is necessary to establish the sensitivity and specificity of this methodology, and Dr Ramella-Romans’ team is scheduled to travel to Mysore in summer 2018 for further testing.

Ultimately the development of this easy-to-use imaging system for the diagnosis of cervical cancer is potentially life changing for many women with little or no access to specialized healthcare.